Reducing calorie intake slows aging and significantly delays the onset of age-related problems such as cardiovascular disease, diabetes, cancer, and brain atrophy in monkeys, a new study says.

    It's likely that reducing caloric intake would have the same positive effects in people, researchers report in the journal Science.

    During the 20-year study, 50% of the monkeys allowed to eat freely have survived, while 80% that ate the same foods but with 30% fewer calories remain alive, University of Wisconsin-Madison scientists say.

    "This is the largest and most highly controlled study showing the beneficial effects of calorie restriction on disease and survival in a primate species," study author Ricki J. Colman, PhD, of the Wisconsin National Primate Research Center, tells WebMD. "We believe that what works in primates will work in humans because primates are so closely related to humans. This has allowed us to understand the mechanisms of the aging process."

    The message for all human adults, and especially for younger people, is to reduce caloric intake permanently and you'll likely "experience the same benefits," Colman tells WebMD.

    Calorie-Restricted Diet Increases Survival

    The research started with 30 rhesus macaques in 1989 to chart the health effects of a calorie-restricted diet and expanded in 1994 with the addition of 46 more.

    All of the animals were enrolled as adults, at ages from 7 to 14. The researchers write that of the original 76 animals in the study, 37% of the control monkeys died of age-related causes, compared to only 13% on a calorie-restricted diet.

    Rhesus macaques have an average life span of 27 years in captivity, and the oldest one still in the study is 29.

    Looking at overall animal health, the calorie-restricted diet leads to longer life span and improved quality of life in old age, Richard Weindruch, PhD, a professor of medicine at the University of Wisconsin-Madison School of Medicine and Public Health and co-author of the study, says in a news release.

    "There is a major effect of caloric restriction in increasing survival if you look at deaths due to the diseases of aging," he says.

    According to the study, the incidence of cancerous tumors and cardiovascular disease in the monkeys on a restricted diet was half that seen in the animals that were allowed to eat freely.

    Although diabetes or prediabetes was seen in 42% of the monkeys that could eat all they want, it has yet to be seen in any animal on the calorie-restricted diet, the researchers say, adding that they consider this result remarkable.

    "So far, we've seen the complete prevention of diabetes," Weindruch says.

    減少卡路里攝取量顯著減緩老化和延誤的發(fā)生與年齡有關(guān)的問題，如心血管疾病，糖尿病，癌癥和腦萎縮的猴子，一項(xiàng)新的研究說。

    很可能是減少熱量攝入也具有同樣的積極效果的人，研究人員在科學(xué)雜志。

    在20年的研究中， 50 %的猴子吃允許自由存活下來，而80 %的人吃同樣的食物，但熱量少30 %仍然活著，威斯康星大學(xué)麥迪遜分校的科學(xué)家說。

    這是最大的和最高度的對(duì)照研究顯示的有利影響的熱量限制的疾病和生存的靈長(zhǎng)類物種， "研究作者Ricki學(xué)者科爾曼博士的威斯康星國家靈長(zhǎng)類動(dòng)物研究中心，告訴訊。 "我們相信，是什么在起作用將工作在靈長(zhǎng)類動(dòng)物，因?yàn)槿祟惖撵`長(zhǎng)類動(dòng)物是如此密切相關(guān)的人類。這使我們能夠理解的機(jī)制老化過程。 "

    該消息對(duì)所有人權(quán)的成年人，尤其是年輕的人，是減少熱量攝入永久和您可能會(huì)"的經(jīng)驗(yàn)同樣的福利， "科爾曼告訴訊。

    限制熱量飲食增加生存

    這項(xiàng)研究始于30獼猴，以圖在1989年對(duì)健康影響的限制熱量飲食和擴(kuò)大1994年增加了46個(gè)以上。

    所有的動(dòng)物被錄取為成人，年齡在7日至14日。研究人員撰寫原始76動(dòng)物研究中， 37 %的控制猴子死于與年齡有關(guān)的原因，相比之下，只有13 %的限制熱量飲食。

    獼猴平均壽命為27年囚禁，以及最古老的一個(gè)仍然在研究29 .

    從整體動(dòng)物健康，限制熱量飲食會(huì)導(dǎo)致較長(zhǎng)的壽命和生活質(zhì)量的提高在年老，理查德Weindruch ,博士，醫(yī)學(xué)教授在威斯康星大學(xué)麥迪遜分校醫(yī)學(xué)院和公共衛(wèi)生與合作作者的研究說，在一個(gè)新聞發(fā)布會(huì)。

    "有重大影響的熱量限制在提高生存如果你看看死于疾病的老齡化， "他說。

    根據(jù)這項(xiàng)研究，在腫瘤的發(fā)病率和心血管疾病中的猴子對(duì)飲食是有限制的一半，看到的動(dòng)物，被允許自由進(jìn)食。

    雖然糖尿病或前期被認(rèn)為在42 %的猴子，可以吃所有他們想要的，但它尚未看到任何動(dòng)物的限制熱量飲食研究人員說，補(bǔ)充說，他們認(rèn)為這樣的結(jié)果顯著。

    "到目前為止，我們已經(jīng)看到了完整的預(yù)防糖尿病， " Weindruch說。